The Effect of Azathioprine on the Lung after Hemorrhagic ShockA Histopathologic Study
作者:
MORRIS KERSTEIN,
CANDACE CORSON,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1980)
卷期:
Volume 20,
issue 5
页码: 407-409
ISSN:0022-5282
年代: 1980
出版商: OVID
数据来源: OVID
摘要:
&NA;A study of hemorrhagic shock in anemic dogs suggested a difference in pulmonary histopathology between animals treated with azathioprine and animals in a control group. Hemorrhagic shock for 2 hours without reinfusion produced definite changes in pulmonary anatomy by conventional histology and electron microscopy. The changes consisted of interstitial edema, vascular congestion, and focal atelectasis. Electron microscopic studies showed accumulation of edema fluid with disruption of Type II pneumocytes and the collagen fibrils in the alveolar‐capillary interstitium. Azathioprine ameliorated the shock state.
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