Effect of Tamoxifen Administration on Prolactin Release by Invasive Prolactin-Secreting Pituitary Adenomas
作者:
Steven W.J. Lamberts,
Theo Verleun,
Rob Oosterom,
期刊:
Neuroendocrinology
(Karger Available online 1982)
卷期:
Volume 34,
issue 5
页码: 339-342
ISSN:0028-3835
年代: 1982
DOI:10.1159/000123324
出版商: S. Karger AG
关键词: Prolactin;Pituitary tumors;Bromocriptine;Tamoxifen;Antiestrogens
数据来源: Karger
摘要:
Bromocriptine treatment of patients with invasive prolactin (PRL)-secreting pituitary adenomas does not invariably result in normalization of the plasma PRL levels. We previously showed that the antiestrogenic drug tamoxifen inhibited hormone release from transplantable PRL-secreting pituitary tumors in rats. In 8 patients with invasive PRL-secreting pituitary adenomas with extrasellar extension, the effect of the administration of tamoxifen was investigated on the plasma PRL concentration and on the bromocriptine-mediated inhibition of PRL release. Treatment for 5 days with tamoxifen (20 mg/day) suppressed plasma PRL levels as measured in 5 samples over the day significantly by 20 ± 3% (means ± SEM; p < 0.01). During tamoxifen administration the inhibition of PRL secretion by 2.5 mg bromocriptine was further suppressed by 36 ± 7%, in comparison with the plasma PRL levels after bromocriptine alone (p < 0.0
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