Use of ketamine in asthmatic children to treat respiratory failure refractory to conventional therapy
作者:
MICHAEL ROCK,
SANTIAGO DE LA ROCHA,
CHARLES L'HOMMEDIEU,
EDWARD TRUEMPER,
期刊:
Critical Care Medicine
(OVID Available online 1986)
卷期:
Volume 14,
issue 5
页码: 514-516
ISSN:0090-3493
年代: 1986
出版商: OVID
数据来源: OVID
摘要:
We treated two pediatric patients suffering respiratory failure associated with status asthmaticus. Neither patient responded to maximal bronchodilatory therapy and mechanical ventilation; however, continuous infusion of ketamine (1.0 to 2.5 mg/kg-h) immediately improved airway obstruction. Ketamine appears to increase catecholamine levels and directly relax bronchial smooth muscle. Except for increased secretions during the infusion, our patients showed no immediate or long-term sequelae from ketamine therapy. However, ketamine should only be used for asthmatics whose respiratory failure does not respond to conventional management and mechanical ventilation.
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