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Ganglionic Action of Angiotensin Contributes to Sympathetic Activity in Renin-Angiotensinogen Transgenic Mice

 

作者: Xiuying Ma,   Curt Sigmund,   Shawn Hingtgen,   Xin Tian,   Robin Davisson,   Francois Abboud,   Mark Chapleau,  

 

期刊: Hypertension: Journal of The American Heart Association  (OVID Available online 2004)
卷期: Volume 43, issue 2, Part 2  

页码: 312-316

 

ISSN:0194-911X

 

年代: 2004

 

出版商: OVID

 

关键词: renin-angiotensin system;sympathetic nervous system;hypertension, genetic;receptors, angiotensin II;losartan;mice

 

数据来源: OVID

 

摘要:

Abstract—In addition to central nervous system actions, angiotensin (Ang) II may increase sympathetic nerve activity (SNA) via a direct action on sympathetic ganglia. We hypothesized that sympathetic ganglionic actions of endogenous Ang II contribute to SNA in transgenic mice that overexpress renin and angiotensinogen (R+A+mice). Renal SNA and arterial pressure were recorded in anesthetized R+A+and littermate control mice before and after ganglionic blockade, and after additional blockade of angiotensin type 1 (AT1) receptors with losartan. Ganglionic blockade essentially abolished SNA in control mice, but only reduced SNA to 47±18% of baseline in R+A+mice. The residual SNA remaining after ganglionic blockade in R+A+mice was reduced from 47±18% to 8±6% of baseline by losartan (P<0.05). The sympathoinhibitory response to losartan was accompanied by an enhanced decrease in arterial pressure in R+A+mice compared with that observed in control mice. AT1receptor expression in sympathetic ganglia, as measured by real-time reverse transcription–polymerase chain reaction, was increased ≈3-fold in R+A+versus control mice. The results demonstrate that, as anticipated, essentially all of the renal postganglionic SNA in control mice is driven by preganglionic input. The major new finding is that Ang II–evoked ganglionic activity accounts for ≈40% of total SNA in R+A+mice. The significant contribution of the direct ganglionic action of Ang II in R+A+mice likely reflects both increased levels of Ang II and upregulation of AT1receptors in sympathetic ganglia.

 

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