5–Fluorouracil/Chemosurgery for Intraepithelial Neoplasia of the Lower Genital Tract
作者:
FREDERICK SILLMAN,
JOHN BOYCE,
MILAGROS MACASAET,
ANTHONY NICASTRI,
期刊:
Obstetrics & Gynecology
(OVID Available online 1981)
卷期:
Volume 58,
issue 3
页码: 356-360
ISSN:0029-7844
年代: 1981
出版商: OVID
数据来源: OVID
摘要:
Sixteen patients with lower genital intraepithelial neoplasia were treated by 5-fluorouraciI (5-FU)/chemosurgery: colposcopically directed excision of neoplastic epithelium pretreated with topical 5-FU. 5-FU loosens the neoplastic epithelium, facilitating its removal from the underlying stroma in a safe, minimally traumatic fashion. 5-FU/ chemosurgery was undertaken in patients with vaginal neoplasia or those with lower genital neoplasia who were immunosuppressed or had a neoplastic syndrome, because conventional methods are often difficult or inadequate for these problems. In all 16 patients, the neoplasia went into remission. Two immunosuppressed patients developed recurrences of lesser dysplasia when 5-FU maintenance therapy was interrupted because of pregnancy. It was found that 5-FU/chemosurgery, followed by monthly 5-FU maintenance, may be the best treatment for intraepithelial neoplasia of the vagina or lower genital intraepithelial neoplasia in patients who are immunosuppressed or have neoplastic syndrome.
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