Cytoskeleton abnormalities in human senile cataract
作者:
TagliaviniJ.,
GandolfiS. A.,
MarainiG.,
期刊:
Current Eye Research
(Taylor Available online 1986)
卷期:
Volume 5,
issue 12
页码: 903-910
ISSN:0271-3683
年代: 1986
DOI:10.3109/02713688608995170
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The cytoskeletal pattern of the most superficial layers (cortex and epithelium) of senile cataractous lenses has been analyzed by PAGE-SDS. While the nuclear type of cataract and age-matched transparent human lenses have super-imposable protein patterns, lenses with cortical cataract demonstrate appreciable modifications of their cytoskeletal composition. The most evident change is the decrease of fodrin and the marked reduction or even the absence of the 98 Kd band. Fodrin may be completely removed from the water insoluble fraction (WIF) of cortical cataract by extraction in low ionic strenght buffer, a treatment which only partially solubilizes this protein in transparent control lenses.
点击下载:
PDF (489KB)
返 回