The neurotoxins 2,5‐hexanedione and acrylamide promote aggregation of intermediate filaments in cultured fibroblasts
作者:
Heather D. Durham,
Sergio D. J. Pena,
Stirling Carpenter,
期刊:
Muscle&Nerve
(WILEY Available online 1983)
卷期:
Volume 6,
issue 9
页码: 631-637
ISSN:0148-639X
年代: 1983
DOI:10.1002/mus.880060903
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractAxonal swellings associated with large aggregates of neurofilaments are characteristic of neuropathies caused by chemical neurotoxins (nhexane, methyl n‐butyl ketone, and acrylamide) or giant axonal neuropathy (GAN—an autosomal recessive genetic disease). In GAN, filamentous aggregates have been shown also to occur in other cell types including cultured skin fibroblasts. Therefore, we studied the effects of 2,5‐hexanedione (the neurotoxic metabolite of n‐hexane and methyl n‐butyl ketone) and acrylamide on normal human skin fibroblasts in tissue culture. We show that both neurotoxins induce aggregation of intermediate, filaments of the vimentin type in the cultured fibroblasts without disrupting mic
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