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Determination of Canrenone in Spironolactone Using Second Derivative Spectrophotometry

 

作者: Abdel-AzizM. Wahbi,   M.S. Mahrous,   Y.A. Beltagy,   A.S. Issa,   H. Lymona,  

 

期刊: Spectroscopy Letters  （Taylor Available online 1992）
卷期: Volume 25, issue 5  

页码: 721-732

 

ISSN:0038-7010

 

年代: 1992

 

DOI:10.1080/00387019208020704

 

出版商: Taylor & Francis Group

 

关键词: Canrenone;Spironolactone;Derivative Spectrophotometry;Impurity

 

数据来源: Taylor

 

摘要:

Second derivative spectrophotometry has been used to determine canrenone (I), the main degredation product in spironolactone (II). Second derivative at 300 nm was found linearly related to concentration in the range of 0.2–1 mg% I has been determined in II down to concentration level of 0.2 mg%. The results were found reproducible with a relative standard deviation of 1.7%.

 

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