Genetic Intervention for Therapy and Prevention of Pancreatic Cancer
作者:
Nicholas R. Lemoine,
期刊:
Digestive Surgery
(Karger Available online 1994)
卷期:
Volume 11,
issue 3-6
页码: 170-177
ISSN:0253-4886
年代: 1994
DOI:10.1159/000172250
出版商: S. Karger AG
关键词: Gene therapy;prodrug activation;Oncogene;Pancreatic cancer
数据来源: Karger
摘要:
Genetic intervention is now a rational therapy for cancer, both to treat established malignancy and to reduce risk in predisposed individuals. Somatic gene therapy can be grouped into tumour suppressor gene replacement, oncogene blockade, genetic immunomodulation, genetic prodrug activation and polynucleotide vaccination. Each of these approaches has potential applications in pancreatic cancer, and this tumour type may be a suitable model for clinical trial.
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