The implantable cardioverter-defibrillator (ICD) represents an important advance in the treatment of ventricular arrhythmias, but infection has remained a serious complication of device implantation. Fungal infections associated with these devices are uncommon, with only 4 cases previously reported. We describe a case of ICD-associated endocarditis caused byCandida albicansthat was successfully treated with complete device explantation and prolonged antifungal therapy, and we review the features of ICD-related fungal infections.