Erythropoietin Secretion in Patients with Chronic Renal Failure after Pure Oxygen Breathing
作者:
F. Kokot,
E. Franek,
M. Kokot,
A. Wiecek,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 4
页码: 436-440
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188018
出版商: S. Karger AG
关键词: Erythropoietin;Chronic renal;Oxygen breathing
数据来源: Karger
摘要:
The present study aimed to assess the relationship between erythropoietin (EPO) secretion and hyperoxemia in uremic patients. In 19 patients with chronic renal failure (10 were hemodialyzed and 9 were not dialyzed) and in 13 healthy subjects plasma erythropoietin levels were assessed during 6 h of air breathing and a second time during 2 h of pure oxygen breathing and during 4 h after discontinued oxygen breathing. Under basal conditions, uremic patients showed higher plasma erythropoietin levels (39.85 ± 5.86 mU/ml in hemodialyzed and 29.05 ± 4.94 mU/ml in nondialyzed patients) as compared with healthy controls (21.04 ± 1.77 mU/ml). Pure oxygen breathing was followed by a significant decline of plasma EPO levels both in patients with chronic renal failure and in the control group. However, this decline was significantly less marked and of longer duration in chronic renal failure patients than in healthy contro
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