Treatment of facial synkinesis and facial asymmetry with botulinum toxin type A following facial nerve palsy
作者:
M.W.J. ARMSTRONG,
R.E. MOUNTAIN,
J.A.M. MURRAY,
期刊:
Clinical Otolaryngology&Allied Sciences
(WILEY Available online 1996)
卷期:
Volume 21,
issue 1
页码: 15-20
ISSN:0307-7772
年代: 1996
DOI:10.1111/j.1365-2273.1996.tb01018.x
出版商: Blackwell Publishing Ltd
关键词: synkinesis;facial palsy;botulinum toxin;complications
数据来源: WILEY
摘要:
Treatment of facial synkinesis and facial asymmetry with botulinum toxin type A following facial nerve palsyFacial synkinesis and asymmetry commonly impair the outcome of facial nerve palsy. Botulinum toxin type A is a neurotoxin which prevents acetylcholine release at the neuromuscular endplate, paralysing skeletal muscle. This paper examines its use in 24 patients with synkinesis and asymmetry affecting the eye and mouth. Sixty‐eight of 72 treatments produced improved cosmesis. Dose‐related complications occurred in 26 treatments but were generally mild and transient. The total dosages of toxin used were analysed. The higher dose group compared with the lower dose group had no significant advantage in overall cosmetic improvement but the complication rate was significantly higher in the higher dose group (20/39) compared with the lower dose group (6/33) (X26.675,P>0.
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