Glucose released from complement mediated immuno-specific damage of glucose loaded lipososmes sensitized with lipid antigens was detected by an amperometric glucose enzyme electrode in view of devising a simple method for electrochemical immunoassay. This method involves the indirect determinatio of antibody and complement levels by measurement of the relesed glucose. The results were correlated with those obtained by the prevous spectrophotometric method with excellent accuracy, indicating that the amperometric enzyme electrode can be another substitute for the previous spectrophotometric detectin of glucose released from immune lysis of liposme loaded with glucose.