Simultaneous Determination of Cephalexin and Carbocisteine from Capsules by Reverse Phase High Performance Liquid Chromatography (RP - HPLC).
作者:
A.P. Argekar,
S.V. Raj,
S.U. Kapadia,
期刊:
Analytical Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 4
页码: 821-831
ISSN:0003-2719
年代: 1997
DOI:10.1080/00032719708006427
出版商: Taylor & Francis Group
关键词: RP - HPLC;Cephalexin;Carbocisteine;Reverse Phase;Capsules
数据来源: Taylor
摘要:
A new, simple, precise, accurate and rapid RP- HPLC method has been developed for the simultaneous determination of Cephalexin and Carbocisteine from capsules, using 0.025 M monobasic sodium phosphate: acetonitrile (87:13, v/v) as a mobile phase, and a C8Shodex column as the stationary phase. Detection was carried out using a UV detector at 210 nm. The linearity range for Cephalexin and Carbocisteine were 50 - 300 μg/mL and 40 - 200 μg/mL, respectively. Assay values for Cephalexin and Carbocisteine were 99.46% (R.S.D. - 1.30%) and 99.22% (R.S.D.-1.34%) for Brand 1. and 99.71% (R.S.D. - 1.68%) and 99.43% (R.S.D. - 1.78%) for Brand 2, respectively.
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