Thromboplastin Synthesis in Endothelial Cells
作者:
Kjell Sverre Galdal,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1984)
卷期:
Volume 14,
issue 5
页码: 378-385
ISSN:1424-8832
年代: 1984
DOI:10.1159/000215095
出版商: S. Karger AG
关键词: Endothelial cells;Thromboplastin stimulation;Thromboplastin inhibition;Tissue factor
数据来源: Karger
摘要:
Endothelial cells (EC) in culture produce a procoagulant identified as thromboplastin when stimulated with 12–O-tetradecanoyl-phorbol-13-acetate, phytohemagglutinin, endotoxin, thrombin, histamine or epinephrine. Inducible thromboplastin generation most likely depends on de novo synthesis of RNA and the protein component of thromboplastin, apoprotein III. It is further probably regulated by intracellular mechanisms involving cAMP, transmethylation and calcium ions. The EC thromboplastin response is enhanced in lymphocyte-EC and platelet-EC cocultures and thromboplastin becomes partly available on the cell surface. Levels of procoagulant activity are reached which clearly may be of clinical importance if similar levels appear in viv
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