BackgroundCross-sectional studies on human hypertension have suggested an association between sodium intake and left ventricular hypertrophy (LVH).Methods and ResultsThe effects on LVH of a nonpharmacological treatment program based mainly on sodium restriction were examined by serial echocardiography in a 12-month controlled, randomized study that included 76 previously untreated subjects with uncomplicated mild-to-moderate hypertension. The mean daily sodium excretion of 38 subjects randomized into the treatment group decreased from 195±95 to 94±73 mmol (P< .001) at 6 months and to 109±74 mmol (P< .001) at 12 months. This was accompanied by a weight decrease from 81.4±18.0 to 79.2±17.4 kg (P< .001) at 6 months and to 80.6 ± 17.5 kg (NS) at 12 months. The net blood pressure decrease (difference in change from baseline between the treatment and control groups) was 8.9 mm Hg (P< .001) in systolic blood pressure and 6.5 mm Hg (P< .001) in diastolic blood pressure during the first 6 months and 6.7 mm HgP< .01) in systolic blood pressure and 3.8 mm Hg (P< .01) in diastolic blood pressure during the last 6 months. After 12 months of sodium restriction, left ventricular mass (LVM) had decreased by 5.4% (from 238±63 to 225±51 g,P< .01), and LVM index (LVMI) had decreased by 4.7% (from 123±26 to 117±22 g/m2,P< .05), whereas no changes occurred in these parameters in the control group. In treated subjects with baseline LVMI of more than the median value of 133 g/m2in men and 107 g/m2in women, LVM decreased by 8.6% (from 272±62 to 249±51 g,P< .01), and LVMI decreased by 7.1% from 140±23 to 130±22 g/m2,P< .01). LVM and LVMI remained unchanged in treated subjects with LVMI values equal to or less than the median.ConclusionsOur data suggest that long-term nonpharmacological treatment with moderate sodium restriction decreases LVH.