Trimethoprim-Sulfamethoxazole for the Prevention of Methicillin-Resistant Staphylococcus aureus Pneumonia in Severely Burned Patients
作者:
Akio,
Kimura Toru,
Mochizuki Kenji,
Nishizawa Kunihiro,
Mashiko Yasuhiro,
Yamamoto Toshibumi,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1998)
卷期:
Volume 45,
issue 2
页码: 383-387
ISSN:0022-5282
年代: 1998
出版商: OVID
数据来源: OVID
摘要:
BackgroundPatients with severe burns are at increased risk of developing methicillin-resistant Staphylococcus aureus (MRSA) ventilator-associated pneumonia. This study was designed to determine whether MRSA pneumonia can be prevented by prophylactic administration of trimethoprim-sulfamethoxazole (TMP-SMX).Methodsor=to20%), who required ventilator support. Prophylaxis was done with oral TMP-SMX (80 mg/400 mg) three times daily for 10 days from 4 to 6 days after burn injury. The incidence of MRSA pneumonia and the side effects were evaluated during the administration period.ResultsTwenty-one patients were assigned to receive TMP-SMX, and 19 patients to receive placebo. The incidence of MRSA pneumonia was 4.8% in the TMP-SMX group and 36.8% in the placebo group, showing a significant difference (p = 0.017). No major side effects of therapy were seen in the TMP-SMX group.ConclusionProphylactic treatment with TMP-SMX can prevent MRSA pneumonia in severely burned patients.
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