Classical conditioning increases membrane‐bound protein kinase C in rabbit cerebellum
作者:
John Freeman,
Andrew Scharenberg,
James Olds,
Bernard Schreurs,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 11
页码: 2669-2673
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cerebellum;Classical conditioning;Eyeblink;Learning;Nictitating membrane;Phorbol ester;Protein kinase C;Purkinje cell;Rabbit
数据来源: OVID
摘要:
WE examined membrane-bound protein kinase C (PKC) in the cerebellum of rabbits given paired presentations of a tone conditioned stimulus (CS) that co-terminated with a periocular electrical stimulation unconditioned stimulus (US) or unpaired presentations of the CS and US or restraint in the experimental context. PKC activation was measured by quantitative film autoradiography of [3H]phorbol 12,13-dibutyrate ([3H]PBt2) binding in the molecular and granule cells layers of lobule HVI, anterior vermis and Crus I, and in the dentate/interpositus nuclei. There was a statistically significant increase in [3H]PBt2 binding within the molecular layer of lobule HVI in rabbits given paired training relative to controls. The results indicate PKC activation in lobule HVI may be important in acquisition of conditioned eyeblink responses.
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