Purpose.To describe the epidemiology ofVibrioeye infections.Method.We reviewed the records of a patient from our institution withV. vulnificuskeratitis and conducted a literature search for other cases of ocular infections withVibriospecies.Results.A 39-year-old fisherman was struck in his left eye with an oyster shell fragment, developed suppurativeV. vulnificuskeratitis, and was successfully treated with combined cefazolin and gentamicin. Including our patient, 17 cases of eye infections withVibriospp. have been reported, and 11 (65%) involved exposure to seawater or shellfish. Of the seven cases due toV. vulnificus(six keratitis and one endophthalmitis), six had known exposure to shellfish or seawater along the U.S. coast of the Gulf of Mexico. Of five cases ofV. alginolyticusconjunctivitis, three had been exposed to fish or shellfish. Three infections withV. parahaemolyticus(one keratitis and two endophthalmitis) were reported; two of these occurred in people exposed to brackish water on or near the Gulf Coast. Two cases of postsurgical endophthalmitis, one withV. albensisand one withV. fluvialis,also were reported.Conclusions.In addition to septicemia, gastroenteritis, and wound infections, halophilic noncholeraVibriospecies can cause sight-threatening ocular infections. Ocular trauma by shellfish from contaminated water is the most common risk factor forVibrioconjunctivitis and keratitis. Nearly one half of reportedVibrioinfections of the eye occurred along the U.S. coast of the Gulf of Mexico.