A tetrameric subunit stoichiometry for a glutamate receptor–channel complex
作者:
Itzhak Mano,
Vivian Teichberg,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 2
页码: 327-331
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: AMPA;cRNA;Glutamate receptor;Subunit stoichiometry;Tetramer;Xenopusoocytes
数据来源: OVID
摘要:
THE structure of glutamate receptor–channel (GluR) subunits has recently been shown to differ from that of other ligand-gated channels and to contain a voltage-gated channel-like pore-forming motif. The view that the structure of GluR complexes is similar to the pentameric structure of other ligand-gated channels was questioned here. Studies of the response properties of the GluR1 subunit of the AMPA subtype of GluRs, co-expressinXenopusoocytes with its L646A mutant, which differs only by a greatly reduced sensitivity to quisqualate, provide new evidence suggesting that the GluR1 homomeric receptor channel has a tetrameric structure.
点击下载:
PDF
(510KB)
返 回