An Updated Meta-Analysis of Formaldehyde Exposure and Upper Respiratory Tract Cancers
作者:
James Collins,
John Acquavella,
Nurtan Esmen,
期刊:
Journal of Occupational and Environmental Medicine
(OVID Available online 1997)
卷期:
Volume 39,
issue 7
页码: 639-651
ISSN:1076-2752
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
In this study, we summarize 47 epidemiologic studies related to formaldehyde exposure and use meta-analytic techniques to assess findings for cancers of the lung, nose/nasal sinuses, and nasopharynx. Our analyses indicate that workers with formaldehyde exposure have essentially null findings for lung cancer and a slight deficit of sinonasal cancer. Nasopharyngeal cancer rates were elevated moderately in a minority of studies. Most studies, however, did not find any nasopharyngeal cancers, and many failed to report their findings. After correcting for underreporting, we found a meta relative risk of 1.0 for cohort studies. Case-control studies had a meta relative risk of 1.3. Our review of the exposure literature indicated that the nasopharyngeal cancer case-control studies represented much lower and less certain exposures than the cohort studies. We conclude that the available studies do not support a causal relation between formaldehyde exposure and nasopharyngeal cancer. This conclusion conflicts with conclusions from two previous meta-analyses, primarily because of our consideration of unreported data.
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