Antibacterial Activity of Cefixime againstStreptococcus pneumoniae,Streptococcus pyogenes, andHaemophilus influenzaein the Presence ofMoraxella (Branhamella) catarrhalis
作者:
Toshihiko Yamada,
Yoshiko Yokota,
Fumiaki Ikeda,
Yasuhiro Mine,
Takahide Kitada,
期刊:
Chemotherapy
(Karger Available online 1992)
卷期:
Volume 38,
issue 1
页码: 28-35
ISSN:0009-3157
年代: 1992
DOI:10.1159/000238939
出版商: S. Karger AG
关键词: β-Lactamase;Disk susceptibility;Moraxella (Branhamella) catarrhalis;Streptococcus pneumoniae;Streptococcus pyogenes;Haemophilus influenzae
数据来源: Karger
摘要:
We measured the sizes of the inhibition zones of oral β-lactam antibiotics for Streptococcus pneumoniae, Streptococcus pyogenes and Haemophilus influenzae in the presence of β-lactamase-producing-Moraxella (Branhamella) catarrhalis by the agar double-layer method. The sizes of the zones of amoxicillin for S. pneumoniae alone were the largest, followed in a descending order by those of cefixime and cefaclor. In the presence of 107 CFU/ml of M.(B.) catarrhalis, however, significant reduction of the sizes of the zones was seen with amoxicillin and cefaclor; inhibition with cefixime was nearly unchanged. Similar results were observed in those for S. pyogenes. These variable findings were attributed to the difference in stability of these drugs to the β-lactamase produced by M. (B.) catarrhalis. When the susceptibility of H. influenzae in the presence of 108 CFU/ml of M.(B.) catarrhalis to cefixime, cefoteram, cefpodoxime, cefotiam and cefuroxime was examined, the sizes of the inhibition zones of all the drugs were reduced by the presence of 108 CFU/ml of M.(B.) catarrhalis, but those of cefixime were the largest of all the drugs tested. Our agar double-layer method is simple and useful for evaluating the influence of β-lactamase-producing organism, as M. (B.) catarrhalis, on the disk susceptibility of other pathogens to antibiot
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