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Precision Estimation in Zelen's Single‐Consent Design

 

作者: J. P. Matts,   R. B. McHugh,  

 

期刊: Biometrical Journal  （WILEY Available online 1993）
卷期: Volume 35, issue 1  

页码: 65-72

 

ISSN:0323-3847

 

年代: 1993

 

DOI:10.1002/bimj.4710350107

 

出版商: WILEY‐VCH Verlag

 

关键词: Randomized clinical trial;Consent design;Randomization analysis;Precision;Confidence interval estimation

 

数据来源: WILEY

 

摘要:

AbstractThe precision of a treatment contrast, as conventionally estimated in Zelen's Single‐Consent Design, is shown under randomization theory to be positively biased. The magnitude of this bias is demonstrated and a new statistic is derived which is a consistent estimator of the precision. Confidence interval estimation for the treatment contrast is also presente

 

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