Strong Association of Idiopathic Membranous Nephropathy with HLA-DR2 and MTl in Japanese
作者:
Shigeo Tomura,
Hidehiko Kashiwabara,
Hiroki Tuchida,
Hideo Shishido,
Shunichiro Sakurai,
Tetsuya Miyajima,
Kimiyoshi Tsuji,
Jugoro Takeuchi,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 36,
issue 4
页码: 242-245
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183162
出版商: S. Karger AG
关键词: Idiopathic membranous nephropathy;HLA-DR antigens;MT antigens;Linkage disequilibrium;Immune response genes;Immune suppression genes
数据来源: Karger
摘要:
HLA-A, B, DR, and MT antigens were examined in 50 patients with idiopathic membranous nephropathy (IMN) by the standard microlymphocytotoxicity technique. The frequency of HLA-DR2 was significantly increased in the patients in comparison to the controls. Significant decreases in the frequencies were seen for HLA-DR4, DRw8 and DRw9 in the patients. The linkage disequilibrium between HLA-Bw52 and DR2 was noted in the controls, but it was significantly weaker in the patients. The frequency of MTl was significantly higher, and that of MT3 was significantly lower in the patients as compared with the controls. The findings suggest that an immunological disturbance under the influence of genetic factors may confer a susceptibility to IMN.
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