Quantitative structure‐activity relationship studies of acute toxicity (LD50) in a large series of herbicidal benzimidazoles
作者:
George W. Adamson,
David Bawden,
David T. Saggers,
期刊:
Pesticide Science
(WILEY Available online 1984)
卷期:
Volume 15,
issue 1
页码: 31-39
ISSN:0031-613X
年代: 1984
DOI:10.1002/ps.2780150106
出版商: John Wiley&Sons, Ltd
数据来源: WILEY
摘要:
AbstractQuantitative structure‐activity relationship (QSAR) studies have been carried out on oral rat LD50values, for 129 herbicidal (trifluoromethyl)benzimidazoles, by multiple regression analyses, using computer‐generated descriptors to represent chemical structure, at several levels of specificity. The results permit rationalisation of the structure‐toxicity relationship, particularly the effect of substituent interactions, and allows reliable ‘rough estimate’ prediction of toxicity. However, reliable predictions of high accuracy are not feasible, even from analysis of this large, consistent, congeneric set of data, thus casting doubt on the suitability of the LD50as a biological end‐point
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