Microglial in Neurodegenerative Disorders: Emphasis on Alzheimer’s Disease
作者:
A. McRae,
A. Dahlström,
E.A. Ling,
期刊:
Gerontology
(Karger Available online 1997)
卷期:
Volume 43,
issue 1-2
页码: 95-108
ISSN:0304-324X
年代: 1997
DOI:10.1159/000213838
出版商: S. Karger AG
关键词: Microglia;Alzheimer’s disease;Immune mechanisms;Diagnosis;Therapy;Amyloid
数据来源: Karger
摘要:
Hallmark lesions of Alzheimer’s disease (AD) are filled with reactive immunocompetent microglia, suggesting that immunological abberations may participate in the pathophysiology of this disorder. If immune-mediated processes are closely linked to neuronal breakdown it would be of importance to have a reliable means to detect these processes. Cerebro-spinal fluid microglial antibodies found mainly in AD patients are discussed as such potential sources. These antibodies recognize microglia in the developing rat brain, in neuronal cultures and on AD cortical biopsies. Treatment aimed at downregulating microglial is discussed and may have therapeutic significance for AD patients. Largely this review presents current opinions which support the concept that inflammation and similar immune mechanisms need to be considered as participating in AD patho-genesi
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