The effects of age on glutathione synthesis enzymes in lenses of Old World simians and prosimians
作者:
RathbunWilliam B.,
HolleschauAnn M.,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue 7
页码: 601-607
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689209000733
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The activities ofγ-glutamylcysteine synthetase and glutathione synthetase, the two enzymes required for glutathione synthesis, were determined as a function of age in lenses of three species of Old World higher primates: orangutan, pigtail monkey and olive baboon. These we're compared to enzyme activities in lenses of two prosimians: mouse lemur and galago.γ-Glutamylcysteine synthetase activity decreased as a function of age in all three Old World simians. The rate of decrease was greatest in the juvenile lenses. In contrast, the enzyme activity increased continuously with age in the galago lens. In the mouse lemur the enzyme activity increased per lens, but was constant when expressed as specific activity or as units per gram of lens. The loss of enzyme activity with age was limited to Old World higher primates apparently representing genetic change.Glutathione synthetase activity decreased logarithmically with age in the lenses of all five species.
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