Dietary effects of sodium alginate in humans
作者:
D. M. W. Anderson,
W. G. Brydon,
M. A. Eastwood,
D. M. Sedgwick,
期刊:
Food Additives & Contaminants
(Taylor Available online 1991)
卷期:
Volume 8,
issue 3
页码: 237-248
ISSN:0265-203X
年代: 1991
DOI:10.1080/02652039109373974
出版商: Taylor & Francis Group
关键词: sodium alginate;dietary effects;bulking agent;transit time
数据来源: Taylor
摘要:
Following a 7‐day control period, five male volunteers consumed a weight of sodium alginate corresponding to 175 mg/kg body weight for 7 days, followed by 200 mg sodium alginate per kg body weight for a further 16 days. Measurements before and at the end of the 23‐day period of dietary supplementation showed that sodium alginate acted as a faecal bulking agent for all volunteers, giving a significant(p< 0.01) increase in daily wet weight, and also increases in the water content and daily dry weight, but no change in faecal pH. Although the dietary transit time remained constant for two volunteers, it decreased for two, and increased slightly for one, with little resulting change in the overall mean value. The ingestion of sodium alginate had no significant effect on (a) haematological indices, (b) plasma biochemistry parameters, (c) urinalysis parameters, (d) blood glucose and plasma insulin concentrations, (e) breath hydrogen concentrations. No allergic responses were reported by, nor observed in, any of the volunteers. The study therefore indicates that the ingestion of sodium alginate at a high level for 23 days caused no effects other than those normally associated with a polysaccharide bulking agent; in particular, the enzymatic and other sensitive indicators of adverse toxicological effects remained unchanged.
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