Gamma-Aminobutyric Acid Immunoreactivity in the Enterochromaffin Cells of the Rat Stomach
作者:
Y. Oomori,
H. luchi,
K. Ishikawa,
Y. Satoh,
K. Ono,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 145,
issue 2
页码: 127-131
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147353
出版商: S. Karger AG
关键词: γ-Aminobutyric acid;Enterochromaffin cells;Serotonin;Stomach;Immunohistochemistry
数据来源: Karger
摘要:
The present immunocytochemical study revealed γ-aminobutyric acid (GABA) immunoreactivity in the oxyntic and pyloric mucosa of the rat stomach at light-and electron-microscopic levels. GABA-immunoreactive endocrine cells were numerously seen in the lower half portion of the pyloric mucosa but rarely in the oxyntic mucosa. These cells were round or oval in shape and sometimes had a short cytoplasmic process. Serotonin-immunoreactive enterochromaffin (EC) cells were also observed in the oxyntic and pyloric mucosa of the stomach. The distribution and shapes of the immunoreactive cells were similar to those of the GABA-immunoreactive cells. With a double immunolabeling technique using anti-GABA and antiserotonin serum, GABA-immunoreactive endocrine cells showed serotonin immunoreactivity and were identified as EC cells. At the electron-microscopic level the GABA-immunoreactive cells contained round or oval, spindle-like, pear-shaped granules in EC cells. The immunoreaction product in the EC cells was generally confined to the granular cores. These findings suggest that GAB A may be synthesized in the EC cells and be released from the granules of the cells after adequate stimuli
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