Somatomedin C Response to Growth Hormone in Psychosocial Growth Retardation
作者:
NANCY HOLMES,
SANDRA BLETHEN,
VIRGINIA WELDON,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1984)
卷期:
Volume 288,
issue 2
页码: 86-88
ISSN:0002-9629
年代: 1984
出版商: OVID
关键词: Somatomedin;Growth;Psychosocial dwarfism
数据来源: OVID
摘要:
Three children with psychosocial growth retardation increased their serum somatomedin C levels from 0.20 ± .02 to 0.81 ± 0.2 U/ml in response to exogenous growth hormone. The pattern of somatomedin C response to growth hormone was no different from that seen in 11 prepubertal children with growth hormone deficiency who received growth hormone according to the same acute treatment regimen. This result suggests that the poor growth response of children with psychosocial growth retardation to exogenous growth hormone is not due to an inability to synthesize somatomedin C, and that it may represent a degree of resistance to the actions of somatomedin C.
点击下载:
PDF
(268KB)
返 回