首页   按字顺浏览 期刊浏览 卷期浏览 Altered Cortisol Response and Hippocampal Atrophy in Pediatric HIV Disease
Altered Cortisol Response and Hippocampal Atrophy in Pediatric HIV Disease

 

作者: Sharon Oberfield,   Linda Cowan,   Lenore Levine,   Ajax George,   Raphael David,   Andrew Litt,   Veronica Rojas,   Ram Kairam,  

 

期刊: Journal of Acquired Immune Deficiency Syndromes  (OVID Available online 1994)
卷期: Volume 7, issue 1  

页码: 57-62

 

ISSN:0894-9255

 

年代: 1994

 

出版商: OVID

 

关键词: Hippocampus;Glucocorticoids;Toxicity;HIV infection;Children;Cortisol secretion;Central nervous system damage.

 

数据来源: OVID

 

摘要:

SummaryThe hippocampus is a major center for the regulation of the hypo-thalamic-pituitary-adrenal axis. There is experimental evidence that chronic exposure to high levels of glucocorticoids may be toxic to the hippocampus. We observed elevated mean basal and 60-min cortisol (F) levels in response to adrenocorticotropin stimulation (0.25 mg cortrosyn, i.v. bolus infusion) in 15 children with HIV infection. Furthermore, in eight of the children for whom data was available, in addition to high peripheral cortisol levels, neurologic dysfunction and hippocampal atrophy were noted on CT scan. These preliminary data suggest that in HIV-infected children an altered cortisol secretion may be associated with specific central nervous system damage.

 

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