首页
按字顺浏览
期刊浏览
卷期浏览
Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasa...
|
Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children
作者:
DAVID BERNSTEIN,
LIHAN YAN,
JOHN TREANOR,
PAUL MENDELMAN,
ROBERT BELSHE,
期刊:
The Pediatric Infectious Disease Journal
(OVID Available online 2003)
卷期:
Volume 22,
issue 1
页码: 28-34
ISSN:0891-3668
年代: 2003
出版商: OVID
数据来源: OVID
摘要:
Background.The cold-adapted, trivalent influenza vaccine (CAIV-T) may become an option for annual vaccination. However, there is little information regarding the immune response to repeated immunization with CAIV-T.Objective.To determine the antibody response to repeated immunization with CAIV-T and to compare this with the response after the first CAIV-T immunization.Design and methods.Healthy children were offered CAIV-T immunization for 4 consecutive years, and blood samples were taken from a subset in Years 1, 2 and 4. In Year 4, 156 similarly aged children who had not received influenza vaccine previously were immunized with the same CAIV-T.Results.The H3N2 and B components of the CAIV-T induced high antibody titers in Year 1 that were maintained during 4 years. The H1N1 titers were lower than the H3N2 or B titers. Comparison of the group immunized for 4 consecutive years with the group immunized for the first time revealed the following: (1) before immunization yearly immunized subjects were more likely to be seropositive to each of the three vaccine strains than those immunized for the first time (P< 0.05 for each); (2) after immunization the percentage of seropositive subjects to each of the strains was similar; (3) after immunization titers were higher in the subjects immunized for the first time than those immunized yearly (P< 0.05 for H3N2 and B).Conclusion.Yearly vaccination with CAIV-T induced high antibody titers, especially to the H3N2 and B strains in the vaccines. The titers in those immunized with CAIV-T for the first time were higher than in those immunized for 4 consecutive years.
点击下载:
PDF
(303KB)
返 回
|
|