Glomerular Disease and Human Immunodeficiency Virus Infection in Brazil
作者:
Guilherme Santoro Lopes,
Luiz P. J. Marques,
Lilimar S. Rioja,
Carlos A. Basilio-de-Oliveira,
Albanita V. Oliveira,
Ana Cassia F. Nery,
Omar da Rosa Santos,
期刊:
American Journal of Nephrology
(Karger Available online 1992)
卷期:
Volume 12,
issue 5
页码: 281-287
ISSN:0250-8095
年代: 1992
DOI:10.1159/000168461
出版商: S. Karger AG
关键词: Human immunodeficiency virus nephropathy;Human immunodeficiency virus;Nephrotic syndrome
数据来源: Karger
摘要:
Clinically overt glomerular disease was detected in 6 (1.1%) of 543 patients with HIV infection followed at a Brazilian National Referral Center for AIDS. In 4 cases, glomerulosclerosis was present (focal and segmental in 3, diffuse and global in 1) and rapid progression to terminal renal failure was observed 1-10 months after clinical presentation. The other 2 patients died with normal renal function, and autopsy studies suggested the diagnosis of minimal change disease. Clinically overt glomerular disease was significantly more common among Black patients, whether all the cases with glomerulopathy (p < 0.001) or just the cases with glomerular sclerosis were considered (p = 0.011). Autopsy study of renal fragments from patients without clinical evidence of glomerular disease was additionally performed and revealed the presence of focal and segmental glomerulosclerosis in 3 cases (7.5 %). We concluded that a glomerulopathy with clinicopathological features which match the definition of HIV nephropathy can be found among Brazilian patients with HIV infection. Accordingly to what has been described in American series, Brazilian Black patients seem to be at increased risk of the development of that nephropathy.
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