Isoelectric Focusing and Selectivity Index in IgA Nephrotic Syndrome
作者:
K.T. Woo,
Y.K. Lau,
K.S. Wong,
G.S.L. Lee,
Y.M. Chin,
G.S.C. Chiang,
C.H. Lim,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 4
页码: 408-413
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188013
出版商: S. Karger AG
关键词: IgA nephritis;Nephrotic syndrome;Response to therapy;Isoelectric focusing Selectivity index
数据来源: Karger
摘要:
Proteinuria in 13 patients with IgA nephritis with nephrotic syndrome (IgANS) was analysed by isoelectric focusing (IEF) and compared with 12 patients with minimal change nephrotic syndrome (MCNS) (n = 8) or focal global sclerosis nephrotic syndrome (FGS) (n = 4) to determine the pattern of proteinuria on IEF and to assess the value of IEF and protein selectivity index (SI) as predictors of response to therapy with predisolone or cyclophosphamide. Steroid/cyclophosphamide responsive patients with IgANS had SC:UA (cationic serum albumin with anionic urine albumin) or SA:UC (anionic serum albumin with cationic urine albumin) IEF patterns and steroid/cyclophosphamide unresponsive patients with IgANS had an SC:UC (cationic serum albumin with cationic urine albumin) IEF pattern. The majority of patients with MCNS or FGS who had an SA:UC IEF pattern were steroid responsive. SI was a better predictor of steroid/cyclophosphamide responsiveness in patients with IgANS (r = 0.78, p < 0.002 compared to IEF, r = 0.64, p < 0.02).
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