Pharmacokinetic Aspects on Once-Daily Nortriptyline Administration
作者:
Fredricson Overø,
期刊:
Neuropsychobiology
(Karger Available online 1980)
卷期:
Volume 6,
issue 1
页码: 34-41
ISSN:0302-282X
年代: 1980
DOI:10.1159/000117730
出版商: S. Karger AG
关键词: Nortriptyline;Kinetics;Plasma level;Dosage regimen
数据来源: Karger
摘要:
Steady state nortriptyline plasma levels have been studied in 21 endogenously depressed patients treated with a single 150-mg morning dose and compared to theoretical curves, calculated from previously known kinetic data. Fairly good agreement between predicted and experimentally found concentrations was observed. The fluctuation between maximal and minimal drug levels within the dosage interval was found to be more pronounced than with a t.i.d. dosage regimen, but still limited (mean ratio = 1.54; range = 1.10-2.16), and the minimum levels (mean = 102 ng/ml; range 46-250 ng/ml) were well compatible with published t.i.d. data. The biological half-life (mean = 39 h; range 24-86 h) agreed well with previously published data for volunteers. It is concluded that once-daily administration of nortriptyline results in relatively flat concentration curves as one would expect from the kinetic features of the drug. The clinical outcome is discussed in a separate paper.
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