Radioimmunoassay of Plasma 11-Desoxycorticosterone
作者:
FredesmindaS. Manlimos,
GeorgeB. Maroulis,
GuyE. Abraham,
期刊:
Analytical Letters
(Taylor Available online 1975)
卷期:
Volume 8,
issue 12
页码: 931-938
ISSN:0003-2719
年代: 1975
DOI:10.1080/00032717508059070
出版商: Taylor & Francis Group
关键词: Radioimmunoassay;11-desoxycorticosterone;celite chromatography
数据来源: Taylor
摘要:
This report describes a radioimmunoassay method for the measurement of unconjugated 11-desoxycarticosterone (DOC) in plasma. Utilizing an anti-DOC antiserum cross reacting minimally with the steroids tested, combined with a one step celite microcolumn chromatography, we have measured this steroid accurately in aliquots of plasma from premenopausal female subjects. The plasma levels of DOC obtained by this method agreed well with levels observed in adult women, using other technics. During the 4 menstrual cycles studied, DOC levels were significantly higher in the luteal phases compared to the follicular phases in all 4 subjects.
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