Antiphospholipid Antibodies in Patients with Idiopathic Autoimmune Haemolytic Anemia
作者:
GuzmanJaime,
CabralAntonio R.,
CabiedesJavier,
PitaLuis,
AlarconDonato,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 18,
issue 1
页码: 51-56
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409014679
出版商: Taylor&Francis
关键词: Haemolytic anemia;anti-phospholipid antibodies;anticardiolipin antibodies
数据来源: Taylor
摘要:
Isolated cases of anti-phospholipid antibody (aPL)-associated idiopathic autoimmune haemolytic anemia (IAHA) have been recently described. To assess the significances of this association, we studied by ELISA the presence of aPL in sera from 18 patients with IAHA and 14 patients with non-autoimmune haemolysis (NON-AH). Four IAHA cases and none of the NON-AH controls showed IgM anticardiolipin antibodies (aCL) that crossreacted extensively with zwitterionic as well as with other anionic phospholipids. IgG aCL were detected in 6 patients with IAHA and in 1 patient with NON-AH; there was little cross-reactivity with other phospholipids. Our results suggest that anti-phospholipid antibodies are present in a substantial number of patients with IAHA. This humoral response does not seem to be secondary to the haemolysis proper. The potential pathogenic significance of this finding is discussed.
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