Determination of the Protonation Constants of Gadolinium(Iii) Diethyltriaminepentaacetic Acid by Solvent Extraction and Icp-Aes
作者:
ThomasJ. Manning,
Warren Fiskus,
Mike Mitchell,
Leigh Dees,
期刊:
Spectroscopy Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 3
页码: 463-467
ISSN:0038-7010
年代: 1999
DOI:10.1080/00387019909349998
出版商: Taylor & Francis Group
关键词: magnetic resonance imaging;contrast reagent;protonation;gadolinium;DTPA
数据来源: Taylor
摘要:
The first and second protonation constant (logβ111,logβ121) of the metal-ligand complex Gadolinium(III)-diethyltriamine-pentaacetic acid (DTPA) have been determined to be 2.27 and 1.52 at 25 °C and I = 0.1. A technique in which the three complexes (H2Gd-DTPA, HGd-DTPA−1, Gd-DTPA−2) are separated according to their relative polarity is utilized. An inductively coupled plasma-atomic emission spectrometer (ICP-AES) is used to determine the relative concentrations of each species by monitoring the gadolinium concentration.
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