Evaluation of an Automated Prothrombin Assay Using a Chromogenic Substrate
作者:
J.A. Conkie,
Frances McCall,
Isobel D. Walker,
J.F. Davidson,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1984)
卷期:
Volume 14,
issue 4
页码: 307-311
ISSN:1424-8832
年代: 1984
DOI:10.1159/000215080
出版商: S. Karger AG
关键词: Automated chromogenic assay;Prothrombin determination;Oral anticoagulant therapy
数据来源: Karger
摘要:
The performance of a commercially available assay for the determination of prothrombin by a chromogenic substrate method has been evaluated for use on an automated clinical analyser. The method was rapid and simple; accuracy, precision and sensitivity were satisfactory, while carry-over was negligible. Determinations were performed on 170 plasma samples from patients on long-term oral anticoagulant therapy, using the automated amidolytic method; comparison of the prothrombin levels with results obtained by the prothrombin time and Thrombotest methods provided highly significant correlations.
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