1. Body surface area is a more accurate basis for pediatric dose estimation than dosage based on age or weight.2. If possible, dose determination should be based on dosage clinically established in pediatric patients.3. Pharmacokinetic variables and individual pathological conditions should also be considered in pediatric dosing.4. Psycho-social factors should not be neglected in determining dosage schedules for children.Psycho-social factors should not be neglected in determining dosages for children.