Immunolocalization of NAIP in the human brain and spinal cord
作者:
Giovanna Pari,
Fouad Berrada,
Gail Verge,
George Karpati,
Josephine Nalbantoglu,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 1
页码: 9-14
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Amyotrophic lateral sclerosis;Apoptosis;Neuronal apoptosis inhibitory protein;Spinal muscular atrophy
数据来源: OVID
摘要:
The neuronal apoptosis inhibitory protein (NAIP) is known to have anti-apoptotic functions, and its gene is often mutated in severe cases of spinal muscular atrophy (SMA), a disease characterized by motor neuron degeneration. In this study, we examined the distribution of the endogenous NAIP protein in normal human spinal cord and brain tissue by using a polyclonal antibody against NAIP. Immunohistochemical staining demonstrated that NAIP is strongly expressed in anterior horn and motor cortex neurons of normal brains, and it is not altered in the remaining motor neurons of patients with amyotrophic lateral sclerosis (ALS). NAIP is also located in human fetal neurons and in adult choroid plexus cells. These results suggest that the antiapoptotic molecule NAIP may be important in motor neurons, but it specifically does not appear to be altered in ALS.
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