Cycle delay in irradiated cytochalasin‐induced polykaryons. Does cytoskeleton status affect cell cycle checkpoints?
作者:
H. E. Davies,
J. B. Court,
期刊:
Cell Biology International
(WILEY Available online 1995)
卷期:
Volume 19,
issue 1
页码: 17-24
ISSN:1065-6995
年代: 1995
DOI:10.1006/cbir.1995.1003
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractFollowing exposure of CHO‐K1 cells to137Cs irradiation at doses up to 20Gy, a delay in G2was observed to occur in cells permitted to divide normally, while cells induced to become giants by means of cytochalasin B demonstrated a minimal delay in the transition 2C–8C suggesting that the inhibition of cytokinesis results in modification of one or more cell cycle checkpoints. We postulate that this may occur as a consequence of damage tolerance, or by a feedback loop resulting from the reorganisation of the cytoskeleton that precludes cytokine
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