Determination of Nabumetone and Its Major Metabolite in Plasma and Tablet Formulations by Reverse-Phase HPLC
作者:
IdreesF. Al-Momani,
期刊:
Analytical Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 14
页码: 2485-2492
ISSN:0003-2719
年代: 1997
DOI:10.1080/00032719708001759
出版商: Taylor & Francis Group
关键词: HPLC;reverse phase;nabumetone;stability;analysis
数据来源: Taylor
摘要:
A high performance liquid chromatographic procedure is presented for the determination of nabumetone in pharmaceutical tablets and in plasma. An aliquot of the sample is dissolved in 50% acetonitrile (ACN) containing 4-methoxyacetophenone as an internal standard and chromatographed on a Supelcosil LC-8 (5μ) (150 mm × 4.6 mm i.d.) column. The mobile phase was a mixture of acetonitrile (500 mL), triethylamine (1.5 mL) and glacial acetic acid (8 mL) diluted to 1000 mL, with distilled deionized water. The detection was carried at 270 nm. The method was tested for linearity, recovery and specificity.
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