Brief ReportSumatriptan Does Not Affect Vasopressin Secretion in Humans
作者:
T. Barreca,
R. Franceschini,
A. Cataldi,
A. Garibaldi,
P. Cianciosi,
E. Rolandi,
期刊:
Clinical Neuropharmacology
(OVID Available online 1993)
卷期:
Volume 16,
issue 6
页码: 555-558
ISSN:0362-5664
年代: 1993
出版商: OVID
关键词: Sumatriptan;Vasopressin;Serotonin
数据来源: OVID
摘要:
Summary: The aim of the study was to investigate the effects of a new sero-toninergic drug, sumatriptan, on arginine vasopressin secretion in humans. Plasma vasopressin concentrations were determined in eight healthy volunteers, before and after administration of 6 mg of sumatriptan, or placebo. No changes in hormone levels were found after sumatriptan or placebo administration. The results suggest that in humans serotoninergic mechanisms, which modulate vasopressin secretion, do not involve the serotonin receptor activated by sumatriptan.
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