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Interleukin 12 Augments Natural Killer-Cell Mediated Cytotoxicity in Hairy Cell Leukemia

 

作者: BigdaJacek,   MysliwskaJolanta,   DziadziuszkoRafal,   BigdaJustyna,   MysliwskiAndrzej,   HellmannAndrzej,  

 

期刊: Leukemia&Lymphoma  （Taylor Available online 1993）
卷期: Volume 10, issue 1-2  

页码: 121-125

 

ISSN:1042-8194

 

年代: 1993

 

DOI:10.3109/10428199309147365

 

出版商: Taylor&Francis

 

关键词: Interleukin 12;NK cells;natural killer-cell;cell mediated toxicity;hairy cell leukemia

 

数据来源: Taylor

 

摘要:

Interleukin 12 (IL12, NKSF-natural killer stimulatory factor) was found to stimulate natural killer (NK) cell activity of hairy cell leukemia (HCL) patients. Two patients not responding to IL12 stimulation were also resistant to interferon alpha (IFN alpha)-mediated augmentation of NK activity. IL12 also enhanced slightly the interleukin 2 (IL2)-induced cytotoxicity of HCL patients, while IFN alpha reduced the stimulatory effect of IL2. These data suggest that interleukin 12 has NK modulatory properties in HCL leukemia patients, which may be different from those of IFN alpha.

 

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