Insulin Signal TransductionThe Role of Protein Phosphorylation
作者:
DENNIS PILLION,
SUNG-JIN KIM,
HELEN KIM,
ELIAS MEEZAN,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1992)
卷期:
Volume 303,
issue 1
页码: 40-52
ISSN:0002-9629
年代: 1992
出版商: OVID
关键词: Insulin signal transduction;Protein phosphorylation.
数据来源: OVID
摘要:
Recent evidence suggests that the mechanism of insulin action depends in part on protein phosphorylation on tyrosine residues. A cascade of phosphorylation/dephosphorylation reactions is proposed to modulate multiple enzymes involved in metabolism, protein synthesis, and cell growth. Direct evidence is presented for the phosphorylation of myelin basic protein and microtubule-associated protein 2 on tyrosine residues by the insulin receptor.
点击下载:
PDF
(1437KB)
返 回