Cerebral type of Lewy body disease
作者:
Kenji Kosaka,
Eizo Iseki,
Toshinari Odawara,
Takayuki Yamamoto,
期刊:
Neuropathology
(WILEY Available online 1996)
卷期:
Volume 16,
issue 1
页码: 32-35
ISSN:0919-6544
年代: 1996
DOI:10.1111/j.1440-1789.1996.tb00152.x
出版商: Blackwell Publishing Ltd
关键词: cortical Lewy body;dementia;diffuse Lewy body disease;Lewy body disease
数据来源: WILEY
摘要:
A cerebral type of Lewy body disease (LBD) is proposed. Lewy body disease was split formerly into three types: brainstem type, transitional type and diffuse type. The diffuse type is now called diffuse Lewy body disease (DLBD). These three types are characterized pathologically by the presence of a large number of Lewy bodies in the CNS. In the brainstem type, Lewy bodies are numerous in the brainstem and diencephalon nuclei, and in DLBD, a vast number are present not only in these nuclei but also in the cerebral cortex and amygdala. In the cerebral type of LBD, as many Lewy bodies are found in the cerebral cortex and in the amygdala as there are in DLBD, but only rarely are they present in the brainstem and diencephalon nuclei. Thus, this type of LBD is different from other types in that it has no parkinson pathology. Therefore, parkinsonism fails to occur throughout the whole clinical course of this disease. The existence of a cerebral type of LBD suggests that Lewy bodies occur in the cerebral cortex earlier than in the brainstem nuclei and that cortical Lewy bodies appear even when the mesocortical dopaminergic system is intact. In addition, this might explain why dementia frequently precedes parkinsonism in DLBD.
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