Synthesis and function of mos: The control switch of vertebrate oocyte meiosis
作者:
Fátima Gebauer,
Joel D. Richter,
期刊:
BioEssays
(WILEY Available online 1997)
卷期:
Volume 19,
issue 1
页码: 23-28
ISSN:0265-9247
年代: 1997
DOI:10.1002/bies.950190106
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractOne distinguishing feature of vertebrate oocyte meiosis is its discontinuity; oocytes are released from their prophase I arrest, usually by hormonal stimulation, only to again halt at metaphase II, where they await fertilization. The product of the c‐mosproto‐oncogene, Mos, is a key regulator of this maturation process. Mos is a serine‐threonine kinase that activates and/or stabilizes maturation‐promoting factor (MPF), the master cell cycle switch, through a pathway that involves the mitogen‐activated protein kinase (MAPK) cascade. Oocytes arrested at prophase I lack detectable levels of Mos, which must be synthesized from a pool of maternal mRNAs for proper maturation. While Mos is necessary throughout maturation inXenopus, it seems to be required only for meiosis II in the mouse. The translational activation of c‐mosmRNA at specific times during meiosis requires cytoplasmic polyadenylation.Cis‐andtrans‐acting factors for polyadenylation are, therefore, essential element
点击下载:
PDF
(692KB)
返 回