Idiosyncratic Pharmacokinetics Complicating Treatment of Major Depression in an Elderly Woman
作者:
JAGA GLASSMAN,
JAMES DUGAS,
MING TSUANG,
DOYNE LOYD,
期刊:
The Journal of Nervous and Mental Disease
(OVID Available online 1985)
卷期:
Volume 173,
issue 9
页码: 573-576
ISSN:0022-3018
年代: 1985
出版商: OVID
数据来源: OVID
摘要:
A 64-year-old woman with major depression developed toxic symptoms while on a regimen of 150 to 200 mg/day of desipramine. Her elimination half-life for desipramine was found to be greatly prolonged, at approximately 150 hours. Her ability to metabolize diphenydramine and lorazepam was found to be impaired as well. Study of the elimination kinetics of desipramine in three of the patient's sisters provided some support for the existence of a genetically determined metabolic defect. Knowledge of those idiosyncratic pharmacokinetics had important implications for diagnosis and treatment in this case.
点击下载:
PDF
(378KB)
返 回