Successful treatment of refractory anemia with high‐dose methylprednisolone
作者:
Toshiko Motoji,
Masanao Teramura,
Masatomo Takahashi,
Kazuo Oshimi,
Michiko Okada,
Kiyoko Kusakabe,
Hideaki Mizoguchi,
期刊:
American Journal of Hematology
(WILEY Available online 1990)
卷期:
Volume 33,
issue 1
页码: 8-12
ISSN:0361-8609
年代: 1990
DOI:10.1002/ajh.2830330103
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: myelodysplastic syndrome;steroid therapy;chromosome abnormalities
数据来源: WILEY
摘要:
AbstractFive patients with refractory anemia were treated with high‐dose methylprednisolone. An immediate and long‐lasting hematological improvement without serious side effects was achieved in two of the patients, although chromosomal abnormalities persisted in both. The clinical course and laboratory data of these two patients are described. Restoration of normal hematopoiesis was achieved regardless of the enhancement of colony formation of granulocyte progenitor cells by the simultaneous addition of hydrocortisone in vitro. The same treatment was given to six patients who had refractory anemia with an excess of myeloblasts (RAEB), but no improvement was observed in any of these patients. It appears that high‐dose methylprednisolone can be valuable in the treatment of refractory anemia, but is not useful for
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